| 软骨细胞氧化应激在骨性关节炎中的作用机制及干预研究进展 |
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投稿时间：2024-08-02
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| 作者 | Author | 单位 | Address | E-Mail |
| 陶叶龙 |
TAO Ye-long |
南通大学第二附属医院 南通市第一人民医院骨科, 江苏 南通 226014 |
Department of Orthopaedics, the 2nd Hospital Affiliated to Nantong University, Nantong First People's Hospital, Nantong 226014, Jiangsu, China |
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| 范建波 |
FAN Jian-Bo |
南通大学第二附属医院 南通市第一人民医院骨科, 江苏 南通 226014
南通大学附属医院骨科, 江苏 南通 226000 |
Department of Orthopaedics, the 2nd Hospital Affiliated to Nantong University, Nantong First People's Hospital, Nantong 226014, Jiangsu, China
Department of Orthopaedics, Affiliated Hospital of Nantong University, Nantong 226000, Jiangsu, China |
fjb@ntu.edu.cn |
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| 期刊信息：《中国骨伤》2025年，第38卷，第4期，第434-440页 |
| DOI：10.12200/j.issn.1003-0034.20240396 |
| 基金项目:南通市自然科学基金(编号:JC2023039) |
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| 中文摘要:随着对骨关节炎发病机制认识的加深,针对软骨细胞氧化应激的治疗策略正逐渐成为研究的热点。本文概述了氧化应激在骨关节炎发展中的重要角色,指出其与软骨细胞衰老、炎症级联反应及软骨基质降解密切相关。鉴于氧化应激在骨关节炎病理过程中的核心作用,抑制氧化应激和活性氧的生成被视为是缓解软骨细胞损伤与衰老、阻止骨关节炎病程进展的关键。尽管当前骨关节炎的研究已取得一定进展,但仍面临诸多挑战,如骨关节炎病因的深入理解、治疗药物的有限选择等。未来的研究将聚焦于更全面地理解氧化应激在骨关节炎中的作用机制,探索新型生物标志物和治疗靶点,以及开发针对氧化应激通路的新型药物或治疗方法。这些努力有望为骨关节炎患者带来更有效的治疗选择,从而改善其生活质量和预后。 |
| 【关键词】骨关节炎 氧化应激 软骨细胞 活性氧 软骨 |
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| Oxidative stress and chondrocytes in osteoarthritis:advances in mechanisms of action and therapeutic strategies |
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| ABSTRACT With the deepening understanding of the pathogenesis of osteoarthritis (OA),therapeutic strategies targeting oxidative stress in chondrocytes have gradually become a research hotspot. This article summarizes the important role of oxidative stress in the development of OA,pointing out that it is closely related to chondrocyte senescence,inflammatory cascade reaction,and cartilage matrix degradation. Given the central role of oxidative stress in the pathological process of OA,inhibiting oxidative stress and the generation of reactive oxygen species (ROS) is considered the key to alleviating chondrocyte damage and senescence,and preventing the progression of OA. Although some progress has been made in current OA research,there are still many challenges,such as the in-depth understanding of the etiology of OA and the limited selection of therapeutic drugs. Future research will focus on a more comprehensive understanding of the mechanism of oxidative stress in OA,exploring new biomarkers and therapeutic targets,and developing new drugs or treatment methods targeting oxidative stress pathways. These efforts are expected to bring more effective treatment options to OA patients,thereby improving their quality of life and prognosis. |
| KEY WORDS Osteoarthritis Oxidative stress Chondrocytes Reactive oxygen species Cartilage |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 陶叶龙,范建波.软骨细胞氧化应激在骨性关节炎中的作用机制及干预研究进展[J].中国骨伤,2025,38(4):434~440 |
| 英文格式: | TAO Ye-long,FAN Jian-Bo.Oxidative stress and chondrocytes in osteoarthritis:advances in mechanisms of action and therapeutic strategies[J].zhongguo gu shang / China J Orthop Trauma ,2025,38(4):434~440 |
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