|ABSTRACT Objective To investigate the clinical efficacy and advantages of total endoscopic I See for single segmental DLSS. Methods The clinical data of 38 patients with single segment DLSS treated by full endoscopic I SEE technique from January 2017 to March 2018 were analyzed retrospectively. there were 16 males and 22 females, aged 35 to 79 years. The mean age was (53.45 ±12.56) years. There were 45 cases of L3~4 5cases, L4~5 23 cases, and L5S1 10 cases . The clinical efficacy was evaluated by VAS, ODI and MacNab. Results All patients were followed up for more than 12 months after operation. The operation time was 55~130min (86 ±17.5 min), the intraoperative blood loss was 10~50 ml (17 ±6 ml), and the hospitalization time was 3~7 days (mean 4.6 days). The VAS score of low back pain was (6.67 ±1.25) before operation and (3.87 ±1.35), (2.55 ±1.21) and (2.05 ±0.97) on the 3rd day, 3rd month and 12th month after operation. The difference was statistically significant (P < 0.05). The VAS score of leg pain before operation (7.85 ±2.62) was significantly different from that on the 3rd day (3.31 ±1.42), 3rd month (2.02 ±1.13) and 12th month (1.85 ±0.86) (P < 0.05). The ODI score was (40.32 ±5.38) before operation and (25.76 ±4.81), (12.66 ±4.64) and (9.32 ±2.91) on the 3rd day, 3rd month and 12th month after operation. The difference was statistically significant (P < 0.05). According to the MacNab evaluation standard of lumbar vertebrae function, 15 cases were excellent, 19 cases were good, 4 cases were fair and 0 cases were poor. the excellent and good rate was 89.47%. Conclusion Full endoscopic I See technique is effective in the treatment of single segmental DLSS with the advantages of less trauma, short hospital stay and rapid recovery.