针灸对原发性骨质疏松症影响的实验和临床研究
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作者Author单位AddressE-Mail
刘献祥 LIU Xian xiang 福建中医学院,福建福州350003 Fujian College of TCM Fujian Fuzhou,350003  
吴明霞 WU Ming xia 福建省第二人民医院,福建福州  
吴炳煌 WU Bing huang 福建中医学院,福建福州350003 Fujian College of TCM Fujian Fuzhou,350003  
章志安 福建中医学院,福建福州350003 Fujian College of TCM Fujian Fuzhou,350003  
钱松涛 福建中医学院,福建福州350003 Fujian College of TCM Fujian Fuzhou,350003  
李俐 福建省第二人民医院,福建福州  
林薇 福建中医学院,福建福州350003 Fujian College of TCM Fujian Fuzhou,350003  
郑良朴 福建中医学院,福建福州350003 Fujian College of TCM Fujian Fuzhou,350003  
林久茂 福建中医学院,福建福州350003 Fujian College of TCM Fujian Fuzhou,350003  
期刊信息:《中国骨伤》2000年,第13卷,第9期,第519-521页
DOI:doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz
基金项目:福建省自然科学基金(No.C97049)
中文摘要:

目的:探讨针刺和艾灸治疗原发性骨质疏松症的疗效。

方法:动物实验采用12月龄雌性大鼠65只,随机分为正常对照组、手术对照组、模型组、雌二醇组、针刺组和艾灸组;采用摘除双侧卵巢法建立骨质疏松症的模型,造模3个月后治疗3个月,进行骨代谢生化指标、性激素水平、骨小梁等观测针刺和艾灸的疗效。临床研究选择骨质疏松女性患者30例,随机分为针刺组和艾灸组各15例,治疗前和治疗3个月检查腰椎骨密度。

结果:经针刺、艾灸或雌二醇治疗后,SAKP、UCa/Cr、UHOP/Cr较模型组分别有所下降;SE2、SBGP较模型组升高(p<0.05~0.01);骨小梁与髓腔的宽度比值,针刺、艾灸和雌二醇较模型组接近正常。30例骨质疏松患者骨密度治疗前和治疗后,针刺和艾灸组分别提高195%和243%.

结论:针刺、艾灸和雌二醇三者的作用无明显差异,针灸是防治骨质疏松症的有效方法之一。
【关键词】骨质疏松  骨密度  针刺疗法
 
Experimental and clinical studies of effects of acupuncture and moxibustion on primary osteoporosis
ABSTRACT  

Objective:To explore experimental and clinical results of acupuncture and moxibustion for the treatment of primary osteoporosis.

Methods:65 female S.D.rats aged 12 months were randomly divided into 6 groups:normal control group,Sham operated group,models group,estradiol group,acupuncture group,moxibustion group.Osteoporosis models were produced by bilateral ovariectomy.The treatment was carried out in models of 3 months and the treatment period lasted for 3 months.The effect of acupuncture and moxibustion was determined by the measurement of the biochemical indexes of bone metabolism,the level of sex hormone and bone morphometry.In the clinical tests,30 female cases of osteoporosis were randomly divided into two groups:acupuncture group and moxibustion group.Bone density of lumbar vertebral was determined at 3 months before treatment and after treatment.

Results: After the treatment,serum AKP,Urine Ca/Cr,Urine HOP/Cr in the estradiol group,acupuncture group and moxibustion group were significantly lower than those in the model group;serum estradiol(E 2),BGP in the estradiol group,acupuncture group and moxibustion group were significantly higher than those in the model group(p<0 05~0 01);the width ratio of bone trabecula to marrow cavity in the estradiol group,acupuncture group and moxibustion group was close to normal standard than that in the model group.Before and after treatment,the bone density of 30 cases in the acupuncture group and moxibustion group raised 1 95% and 2 43% respectively.

Conclusion:There were no significant differents among the therapy of acupuncture,moxibustion and serum estradio.Acupuncture and moxibustion was effective way for the treatment and prevention of osteoporosis.
KEY WORDS  Osteoporosis  Bone  density  Acupuncture  therapy
 
引用本文,请按以下格式著录参考文献:
中文格式:刘献祥,吴明霞,吴炳煌,章志安,钱松涛,李俐,林薇,郑良朴,林久茂.针灸对原发性骨质疏松症影响的实验和临床研究[J].中国骨伤,2000,13(9):519~521
英文格式:LIU Xian xiang,WU Ming xia,WU Bing huang.Experimental and clinical studies of effects of acupuncture and moxibustion on primary osteoporosis[J].zhongguo gu shang / China J Orthop Trauma ,2000,13(9):519~521
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