| 骨代谢水平与膝骨关节炎疼痛的临床相关性研究 |
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Received:February 10, 2025
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| 作者 | Author | 单位 | Unit | E-Mail |
| 孙镛奇 |
SUN Yong-qi |
浙江中医药大学, 浙江 杭州 310059 |
Zhejiang Chinese Medical University, Hangzhou 310059, Zhejiang, China |
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| 郭克淳 |
GUO Ke-chun |
浙江中医药大学, 浙江 杭州 310059 |
Zhejiang Chinese Medical University, Hangzhou 310059, Zhejiang, China |
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| 刘泽中 |
LIU Ze-zhong |
湘潭市中医医院, 湖南 湘潭 411100 |
Xiangtan Hospital of Traditional Chinese Medicine, Xiangtan 411100, Hunan, China |
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| 段金帅 |
DUAN Jin-shuai |
浙江中医药大学附属温州中西医结合医院骨伤科, 浙江 温州 325000 |
Zhejiang Chinese Medical University Affiliated Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou 325000, Zhejiang, China |
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| 许兵 |
XU Bing |
浙江中医药大学附属温州中西医结合医院骨伤科, 浙江 温州 325000 |
Zhejiang Chinese Medical University Affiliated Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou 325000, Zhejiang, China |
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| 骆国钢 |
LUO Guo-gang |
浙江中医药大学附属温州中西医结合医院骨伤科, 浙江 温州 325000 |
Zhejiang Chinese Medical University Affiliated Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou 325000, Zhejiang, China |
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| 赖宪良 |
LAI Xian-liang |
浙江中医药大学附属温州中西医结合医院骨伤科, 浙江 温州 325000 |
Zhejiang Chinese Medical University Affiliated Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou 325000, Zhejiang, China |
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| 王萧枫 |
WANG Xiao-feng |
浙江中医药大学附属温州中西医结合医院骨伤科, 浙江 温州 325000 |
Zhejiang Chinese Medical University Affiliated Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou 325000, Zhejiang, China |
1139165152@qq.com |
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| 期刊信息：《中国骨伤》2025年25卷，第5期，第482-486页 |
| DOI：10.12200/j.issn.1003-0034.20240038 |
| 基金项目:国家中医药管理局科技司-浙江省中医药管理局共建重点项目(编号:GZY-ZJ-KJ-23093);浙江省自然基金项目(编号:Y23H270001);教育部产学合作协同育人项目(编号:202102242025);浙江中医药大学附属医院科研专项(编号:2021FSYYZZ30) |
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目的:探讨骨代谢水平在不同人群之间的差异性及其与膝骨关节炎(knee osteoarthritis,KOA)疼痛间的关联。
方法:选取2023年1月至2023年6月参加体检者50例(对照组),男26例,女24例;年龄41~65(52.14±9.04)岁;并选取门诊就诊的50例KOA患者(病例组),男19例,女31例;年龄40~65(53.60±7.76)岁。比较两组西安大略和麦克马斯特大学骨关节炎指数(Western Ontario and McMaster Universities Osteoarthritis index,WOMAC) 及骨代谢相关标志物,如25羟基维生素D[25-hydroxy-cholecalciferol,25(OH)D]、β-胶原降解产物(β-isomerized typeⅠcollagen C-telopeptide breakdown products,β-CTX)、Ⅰ型胶原氨基端前肽(total typeⅠprocollagen N-terminal propeptide,t-PINP)、骨钙素(osteocalcin,OC)、甲状旁腺激素(parathormone,PTH)水平。采用Pearson相关分析比较两组骨代谢相关标志物与WOMAC的相关性。
结果:病例组WOMAC(39.90±2.34)分,高于对照组(3.60±0.57)分,差异有统计学意义(P<0.05)。两组25(OH)D、β-CTX、PTH比较,差异均无统计学意义(P>0.05)。病例组t-PINP、OC分别为(62.90±52.40)、(19.88±10.15) ng·ml-1,对照组分别为(38.86±10.82)、(14.90±3.62) ng·ml-1;病例组t-PINP、OC高于对照组,差异有统计学意义(P<0.05)。Pearson相关分析结果显示,病例组t-PINP与WOMAC疼痛评分呈正向相关性(r2=0.045,P<0.01)。
结论:与健康人群比较,KOA患者血清中OC、t-PINP存在差异,且t-PINP水平和KOA患者疼痛症状呈正相关关系,但KOA患者骨代谢水平与其疼痛症状之间的相关机制有待通过基础实验研究以及扩大样本进一步阐明。 |
| [关键词]:膝骨关节炎 骨代谢水平 疼痛 血液 相关性 |
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| Clinical correlation study between bone metabolism level and knee osteoarthritis pain |
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Abstract:
Objective To investigate the variability of bone metabolism levels among different populations and its association with knee osteoarthritis (KOA) pain.
Methods A total of 50 people (control group) who participated in physical examination from January 2023 to June 2023 were selected,including 26 males and 24 females,wtih a mean aged of (52.14±9.04) years old ranging 41 to 65 years old. The other 50 patients with knee osteoarthritis(case group) who attended the outpatient clinic of the Orthopedics and Traumatology Department in the same time period,including 19 males and 31 females,with a mean age of (53.60±7.76) years old ranging 40 to 65 years. The two groups of Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC) and bone metabolism markers,such as 25-hydroxy-cholecalciferol[25(OH)D],β-isomerized typeⅠcollagen C-telopeptide breakdown products (β-CTX),total typeⅠprocollagen N-terminal propeptide (t-PINP),osteocalcin (OC),parathormone (PTH) levels were compared. Pearson correlation analysis was used to compare the correlation between two groups of bone metabolism related markers and WOMAC.
Results The WOMAC score of the case group (39.90±2.34) was higher than that of the control group (3.60±0.57),with significant difference (P<0.05). There was no significant difference between the two groups of 25 (OH)D,β-CTX and PTH (P>0.05). The t-PINP and OC of the case group were (62.90±52.40) and (19.88±10.15) ng·ml-1,respectively,and those of the control group were (38.86±10.82) and (14.90±3.62) ng·ml-1,respectively;the t-PINP and OC of the case group were higher than those of the control group,with significant difference (P<0.05). Pearson correlation analysis showed that t-PINP was positively correlated with WOMAC pain score in the case group (r2=0.045,P<0.01).
Conclusion Bone metabolism levels in the serum of patients with knee osteoarthritis are different from those of healthy people,and the difference between OC and t-PINP is the most obvious,and the concentration of t-PINP levels is positively correlated with pain symptoms in patients with KOA. However,the specific mechanism of correlation between the bone metabolism levels of patients with KOA and their pain symptoms needs to be further elucidated by basic experimental research as well as by enlarging the samples. |
| KEYWORDS:Knee osteoarthritis Bone metabolism levels Pain Blood Correlation |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 孙镛奇,郭克淳,刘泽中,段金帅,许兵,骆国钢,赖宪良,王萧枫.骨代谢水平与膝骨关节炎疼痛的临床相关性研究[J].中国骨伤,2025,25(5):482~486 |
| 英文格式: | SUN Yong-qi,GUO Ke-chun,LIU Ze-zhong,DUAN Jin-shuai,XU Bing,LUO Guo-gang,LAI Xian-liang,WANG Xiao-feng.Clinical correlation study between bone metabolism level and knee osteoarthritis pain[J].zhongguo gu shang / China J Orthop Trauma ,2025,25(5):482~486 |
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