| 中药颈椎Ⅰ号治疗模拟颈神经根炎病理学观察 |
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投稿时间：1998-10-20 修订日期：1998-12-14
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| 期刊信息：《中国骨伤》1999年，第12卷，第6期，第13-15页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目: |
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中文摘要:
目的:为了观察中药颈椎号对模拟颈神经根炎的疗效及作用机理。
方法:将96只模拟颈神经根炎Wistar大鼠随机分为4组:颈椎号中剂量组、颈椎号高剂量组、颈复康组及空白对照组,分别给予颈椎号中剂量、高剂量、颈复康及凉开水,于造模后3天、7天、14天、42天,取神经根进行病理学观察。
结果:颈椎号中剂量、高剂量可以明显减轻模型鼠颈神经根的充血、水肿、淋巴细胞浸润等炎症反应,减轻成纤维细胞和胶原纤维的增多,减轻瘢痕化,促使神经功能恢复。
结论:颈椎号对模拟颈神经根炎具有良好的疗效。 |
| 【关键词】中药颈椎Ⅰ号 模拟颈神经根炎 病理学 |
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| Pathological Observation on the Treatment of the Imitative Cervical Radiculoneuritis with Chinese Medicinal Herbs Decoction Jingzhui No I |
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ABSTRACT
Objective: To study the therapeutic effect of Chinese medicinal herbs decoction, Jingzhui No I(JZ Ⅰ) on imitative cervical radiculoneuritis and its mechanism
Methods: 96 Wistar rats were operated for modelling imitative cervical radiculoneuritis and then divided into 4 groups:moderate and high dosage JZ Ⅰ groups, orally given moderate dosage or high dosage of JZ Ⅰ once per day; Jingfukang (a eutherapeutic Chinese herbs in treating radiculoneuritis) group; and blank control group, given water only 3,7, 14 and 42 days after operation, the nerve roots were taken out for pathological observation
Results: The JZ Ⅰwith moderate and high dosages could obviously alleviate congestion, edema and lymphocyte infiltration of inflammatory reaction at 3 and 7 days after operation; and reduce the proliferation of fibroblasts and collagen fibers, thus reducing cicatrization of the nerve roots at 14 and 42 days after operation .
Conclusion: JZ Ⅰcan alleviate inflammatory reaction, inhibit cicatrization, and promote the recovery of nerve function It is an effective drug in treating imitative cervical radiculoneuritis. |
| KEY WORDS Chinese herbs Jingzhui No I Cervical radiculoneuritis Rat model Pathology |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 张军,孙树椿.中药颈椎Ⅰ号治疗模拟颈神经根炎病理学观察[J].中国骨伤,1999,12(6):13~15 |
| 英文格式: | Zhang Jun,Sun Shuchun.Pathological Observation on the Treatment of the Imitative Cervical Radiculoneuritis with Chinese Medicinal Herbs Decoction Jingzhui No I[J].zhongguo gu shang / China J Orthop Trauma ,1999,12(6):13~15 |
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