| 去睾大鼠骨丢失的组织学机理研究 |
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投稿时间：2000-08-28 修订日期：2000-11-17
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| 期刊信息：《中国骨伤》2001年，第14卷，第4期，第209-211页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:浙江省中医管理局资助项目之一(编号:97003) |
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中文摘要:
目的：探讨雄性大鼠去睾后骨丢失的组织学机理,为临床治疗用药提供理论依据。
方法：将30只10月龄雄性大鼠,用完全随机设计方法分为正常对照组和去睾病理组,每组各15只。饲养12周后处死取腰1～2脊椎,作不脱钙骨切片,测定骨形态计量学各骨量参数和表面参数。两组参数作方差分析,显着性检验。
结果：去睾病理组骨量参数小于正常对照组(P<005),其表面参数显示：成骨参数减少、破骨参数增加、骨转换加快(P<005).
结论：重建负平衡和骨高转换是导致去睾后骨丢失的组织学机理,临床治疗老年男性骨质疏松症应联合应用促进骨形成、抑制骨吸收和降低骨转换药物。 |
| 【关键词】骨质疏松,老年性 骨密度 组织学 |
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| Studies on Histological Mechanism of Bone Loss of Castrated Male Rats |
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ABSTRACT
Objective: To investigate the histological mechanis m of the bone loss of castrated male rat s and provied theoretical basis for clin ical treatment.
Methods: 30 male rats aged 10 months were randoml y divided into two groups as normal and castrated pathological groups.The animal s were sacrificed after adminsration Hei hudan (a TCM agent) for 12 weeks.L 1 and L 2 were chosen to make bone slices with o ut decalificating and then diverse bone indexes and superficial indexes of bone morphological metrology were determined. ANOVA was used for data anlysis.
Results:Bone indexes in the pathological group w ere smaller than the normal one(P<0 05) .The superficial indexes show:osteoclast index increased,osteogenesis index decr eased,bone transformation became faster than before(P<0.05).
Conclusion: Reconstruction of negative balance and h igh bone transformation were the mechani sms of the bone loss of castrated male r ats.The method of combining with drugs t o promote bone formation,restrain bone a bsorption,reduce bone transformation see ms to be useful for the treatment of sen ile male patients with osteoporosis. |
| KEY WORDS Osteoporosis senile Bone density Histology |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 成羿,朱杭,黄海.去睾大鼠骨丢失的组织学机理研究[J].中国骨伤,2001,14(4):209~211 |
| 英文格式: | CHENG Yi,ZHU Hang,HUANG Hai.Studies on Histological Mechanism of Bone Loss of Castrated Male Rats[J].zhongguo gu shang / China J Orthop Trauma ,2001,14(4):209~211 |
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