| 脐血对骨折愈合影响的实验研究 |
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投稿时间：1999-08-26 修订日期：2000-10-25
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| 作者 | Author | 单位 | Address | E-Mail |
| 张会生 |
ZHANG Hui sheng |
中国人民解放军第二五一医院,河北张家口075000 |
The 251 Hospital of PLA,Hebei Zhangjiakou,075000 |
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| 何强 |
HE Qiang |
中国人民解放军第二五一医院,河北张家口075000 |
The 251 Hospital of PLA,Hebei Zhangjiakou,075000 |
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| 李达 |
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中国人民解放军第二五一医院,河北张家口075000 |
The 251 Hospital of PLA,Hebei Zhangjiakou,075000 |
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| 李安民 |
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中国人民解放军第二五一医院,河北张家口075000 |
The 251 Hospital of PLA,Hebei Zhangjiakou,075000 |
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| 李自强 |
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中国人民解放军第二五一医院,河北张家口075000 |
The 251 Hospital of PLA,Hebei Zhangjiakou,075000 |
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| 朱森树 |
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中国人民解放军第二五一医院,河北张家口075000 |
The 251 Hospital of PLA,Hebei Zhangjiakou,075000 |
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| 郝青虎 |
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中国人民解放军第二五一医院,河北张家口075000 |
The 251 Hospital of PLA,Hebei Zhangjiakou,075000 |
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| 期刊信息：《中国骨伤》2001年，第14卷，第11期，第673-674页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目: |
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中文摘要:
目的：探讨同种及异种脐血是否有促进骨折愈合的作用。
方法：72只新西兰大耳兔在实验性胫骨横断骨折固定后,随机被分为兔脐血组、人脐血组、无脐血组及血肿组,每组18只。前三组均于骨折部位置引流管,密闭切口,术后行闭式引流大约24小时,再经皮于骨折处分别注入兔脐血、人脐血及生理盐水3ml,血肿组不引流也不注入任何试剂。分期抽血做免疫学检查,包括IgG和SIL2R,取实验胫骨摄X线片及做光镜、电镜检查。
结果：血肿组较无脐血及血肿组骨折愈合时间短1周,两脐血组间无明显差异,骨愈合时间比上述二组短1～2周左右。免疫学检查术后各组间未见显着性差异。
结论：同种及异种脐血有促进骨折愈合作用。局部注射脐血无异常免疫反应。 |
| 【关键词】骨折愈合 胎血 免疫学试验 |
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| The influence of the umbilical cord blood on fracture healing:an experimental study |
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ABSTRACT
Objective:To explore the effect of homogeneous and heterogenous umbilical cord blood on fracture healing
Methods:After establishment of transverse fracture of tibia,72 New Zealand rabbits were divided into four groups:rabbit umbilical cord blood group,human umbilical cord group,no cord blood group and hematoma group,each of 18 rabbits.In the former three groups,drainage tube was placed in fracture sites and closed drainage was perfromed for about 24 hours.The rabbit umbilical cord blood,human umbilical cord and saline of 3ml were injected into fracture points of the three groups respectively.In hematoma group,drainage was not placed and nothing was injected.Immunologic test including IgG and SIL 2R was done and X ray, optical microscope and electron microscope examination of tibia was also carried out.
Results:The fracture healing during of umbilical cord blood groups were 1 week shorter than that of hematoma group and 2 weeks than that of no cord blood group.The fracture healing during of the two umbilical cord blood groups had no obvious difference.The results of immunologic test showed no obvious difference between the four groups.
Conclusion:Homogeneous and heterogenous umbilicus cord blood were effective in promoting fracture healing.There was no abnormal immunologic reaction after injection of umbilical cord blood in local place. |
| KEY WORDS Fracture healing Fetal blood Immunologic tests |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 张会生,何强,李达,李安民,李自强,朱森树,郝青虎.脐血对骨折愈合影响的实验研究[J].中国骨伤,2001,14(11):673~674 |
| 英文格式: | ZHANG Hui sheng,HE Qiang.The influence of the umbilical cord blood on fracture healing:an experimental study[J].zhongguo gu shang / China J Orthop Trauma ,2001,14(11):673~674 |
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