颈椎失稳所致心肌缺血家兔心肌超微结构的观察
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作者Author单位AddressE-Mail
齐越峰 QI Yue-feng 北京市丰盛中医骨伤专科医院,北京100032 Fengsheng Hospital of Orthopacdics and Traumatology of TCM  
张军 ZHANG Jun 中国中医研究院骨伤科研究所  
孙树椿 SUN Shu-chun 中国中医研究院骨伤科研究所  
付宝弛 FU Bao-chi 抚顺市第三医院  
期刊信息:《中国骨伤》2004年,第17卷,第1期,第7-9页
DOI:doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz
基金项目:
中文摘要:

目的:探讨颈椎错位失稳对缺血心肌超微结构改变的影响。

方法:通过手术切断C5~C6、C6~C7、C7~T1的棘间韧带,旋转错位C6和C7椎体,建立颈椎错位失稳模型。分别在术后1、2、3个月时采用透射电镜观察缺血心肌细胞超微结构的改变情况。

结果:术后1个月心肌细胞无明显改变,术后2、3个月时,心肌细胞的膜性细胞器出现了明显的病理损害,肌丝松散、线粒体肿胀,内嵴损害,糖原颗粒减少,这些表现随着时间的推移逐渐加重。

结论:颈椎长期失稳可引起缺血心肌出现器质性损害;颈椎病可能为冠心病的一个重要病因。
【关键词】颈椎病  心肌缺血  动物,实验
 
Observation on ultrastructure of ischemic myocardium in rabbits with cervical vertebral instability
ABSTRACT  

Objective:To inquire into influence of cervical vertebral instability on the ultrastructure of ischemic myocardium.

Methods:Animal models were made by cutting off supraspinal ligaments of C5~C6, C6~C7, C6~T1,ratating and displacing C6~C7 vertebral bodies.The changes of ultrastructure of ischemic myocardium were observed with electrical microscope at 1,2,3 months after the operation.

Results:At 1 month after operation,no changes were found.But at 2,3 months after operation,pathologic changes of myocardial cell,such as areosis of myofilament,mitochondrial swelling,quantity of crista decreased,were found,which gradually aggravated along with time.

Conclusion:Long-term cervical vertebral instability could induce organic damage of ischemic myocardium.Cervical spondylosis may be an important factor of coronary heart disease.
KEY WORDS  Cervical spondylosis  Myocardial infarction  Animals,laboratory
 
引用本文,请按以下格式著录参考文献:
中文格式:齐越峰,张军,孙树椿,付宝弛.颈椎失稳所致心肌缺血家兔心肌超微结构的观察[J].中国骨伤,2004,17(1):7~9
英文格式:QI Yue-feng,ZHANG Jun,SUN Shu-chun,FU Bao-chi.Observation on ultrastructure of ischemic myocardium in rabbits with cervical vertebral instability[J].zhongguo gu shang / China J Orthop Trauma ,2004,17(1):7~9
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