| 双膦酸盐在骨转移瘤中的应用进展 |
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投稿时间：2007-07-04
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| 期刊信息：《中国骨伤》2008年，第21卷，第6期，第480-482页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目: |
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| 中文摘要:骨转移瘤是肿瘤患者的严重并发症，与骨痛、病理性骨折、神经缺失和(或)高钙血症等紧密相关，因此，骨转移瘤的治疗是必要的。双膦酸盐是标准的治疗和预防骨相关事件的药物，可抑制破骨细胞介导的骨吸收，显示抗癌活性，是最有效的治疗骨转移瘤和预防骨转移并发症的药物，可降低患者骨相关事件的发生，提高患者生活质量。 |
| 【关键词】骨肿瘤 肿瘤转移 二膦酸盐类 综述文献 |
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| The application advances of Bisphosphonates in bone metastasis |
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| ABSTRACT Bone metastases is a serious complication of patients with tumor. It is associated with substantial morbidity,including bone pain,pathological fracture,neurological deficit and(or) hypercalcemia. Thus,the management of bone metastasis is a clinically significant issue. Bisphosphonates have now become a part of standard therapy to treat and prevent skeletal-related events(SRE),it could inhibit osteoclast-mediated bone resorption and demonstrate antitumor activity in preclinical models. Bisphosphonates are the most effective agent for treating and(or) preventing complications of bone metastasis,reducing the incidence of skeletal-related events,and improving quality of life in patients with bone metastasis. |
| KEY WORDS Bone neoplasms Neoplasm metastasis Diphosphonates Review literature |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 梁鹏.双膦酸盐在骨转移瘤中的应用进展[J].中国骨伤,2008,21(6):480~482 |
| 英文格式: | LIANG Peng.The application advances of Bisphosphonates in bone metastasis[J].zhongguo gu shang / China J Orthop Trauma ,2008,21(6):480~482 |
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