| 黄芪对破裂型椎间盘突出重吸收动物模型的影响 |
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投稿时间：2008-09-18
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| 作者 | Author | 单位 | Address | E-Mail |
| 姜宏 |
JIANG Hong |
苏州市中医医院,江苏 苏州 215003 |
The Institute of Spinal Disease,the Shanghai University of TCM, 201203,Shanghai,China |
liujintao0533@yahoo.com.cn |
| 刘锦涛 |
LIU Jin-tao |
上海中医药大学脊柱病研究所 |
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| 惠礽华 |
HUI Reng-hua |
苏州市中医医院,江苏 苏州 215003 |
The Institute of Spinal Disease,the Shanghai University of TCM, 201203,Shanghai,China |
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| 王拥军 |
WANG Yong-jun |
上海中医药大学脊柱病研究所 |
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| 期刊信息：《中国骨伤》2009年，第22卷，第3期，第205-207页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:江苏省中医药局资助项目(编号：200523) |
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中文摘要:
目的：研究破裂型椎间盘突出重吸收过程中免疫反应的作用机制，以及黄芪干预重吸收过程的作用机制。
方法：将28只雄性SD大鼠，随机分为正常组、模型组、黄芪注射液治疗组和胸腺肽治疗组等4组。动物10 d后处死，取髓核组织，进行HE染色观察形态结构变化，流式细胞仪检测T、B细胞含量。
结果：相对于模型组，治疗组大鼠髓核组织的形态结构发生明显变化，T、B细胞含量比例明显大于模型组。
结论：突出髓核组织能够引发自身免疫反应，黄芪对破裂型椎间盘突出的重吸收有一定促进作用，可能是通过增强自身免疫而发挥作用的。 |
| 【关键词】椎间盘移位 模型,动物 自身免疫 中草药 |
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| An experimental study on the influence of radix astragali on the ressorption of ruptured disc herniation |
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ABSTRACT
Objective: To investigate the possible mechanism of immune response in the resorption of the ruptured intervertebral disc herniation,and the possible mechanism of radix astragali on the resorption of the ruptured disc herniation.
Methods: Twenty-eight male SD(Sprague-dawley)rats were chosen. The rats were randomly divided into 4 groups:the control group,model group,the group treated with radix astragali injection and the group treated whit thymic peptide. The rats were killed and discs were harvested 10 days after treatment. Flow cytometry and HE staining were used for analysis of cells and tissue.
Results: Compared with the control group,the proportion of activated T cells(CD4+ and CD8+) and B cells were significantly higher in the two drug-treatment groups.
Conclusion: Herniated nucleus pulposus attracts activated T and B cells and triggered an immune response. Radix astragali could strengthen the autoimmune response. |
| KEY WORDS Intervertebral disk displacement Models,animal Autoimmunity Drugs,Chinese herbal |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 姜宏,刘锦涛,惠礽华,王拥军.黄芪对破裂型椎间盘突出重吸收动物模型的影响[J].中国骨伤,2009,22(3):205~207 |
| 英文格式: | JIANG Hong,LIU Jin-tao,HUI Reng-hua,WANG Yong-jun.An experimental study on the influence of radix astragali on the ressorption of ruptured disc herniation[J].zhongguo gu shang / China J Orthop Trauma ,2009,22(3):205~207 |
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