| 奇正青鹏膏剂外用治疗类风湿关节炎止痛消肿作用的临床对照试验 |
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投稿时间：2009-09-23
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| 作者 | Author | 单位 | Address | E-Mail |
| 周彩云 |
ZHOU Cai-yun |
中国中医科学院西苑医院风湿免疫科,北京 100091 |
The Xiyuan Hospital of China Academy of Chinese Medical Sciences,Beijing 100091,China |
gaozhenpeng@vip.sina.com |
| 潘峥 |
PAN Zheng |
中国中医科学院西苑医院风湿免疫科,北京 100092 |
The Xiyuan Hospital of China Academy of Chinese Medical Sciences,Beijing 100092,China |
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| 马芳 |
MA Fang |
中国中医科学院西苑医院风湿免疫科,北京 100093 |
The Xiyuan Hospital of China Academy of Chinese Medical Sciences,Beijing 100093,China |
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| 唐今杨 |
TANG Jin-yang |
中国中医科学院西苑医院风湿免疫科,北京 100094 |
The Xiyuan Hospital of China Academy of Chinese Medical Sciences,Beijing 100094,China |
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| 期刊信息：《中国骨伤》2009年，第22卷，第12期，第917-919页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目: |
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中文摘要:
目的：评价奇正青鹏膏剂外用对类风湿关节炎关节疼痛肿胀的临床疗效。
方法：自2004年12月至2006年5月采用随机、平行对照临床研究方案，运用区组随机化方法，利用SAS软件的PROC PLAN语句，将78例患者随机分为治疗组和对照组。治疗组40例，男30例，女10例，平均年龄(48.2 ±9.7)岁，用奇正青鹏膏剂外用治疗；对照组38例，男30例，女8例，平均年龄(47.7 ±13.7)岁，用双氯芬酸二乙胺乳胶剂外用。以掌指关节中肿痛最重的一个关节作为观察关节，观察关节疼痛、关节压痛、关节肿胀、关节屈伸不利、晨僵等情况，根据尼莫地平法计算症状积分指数(VAS记分),进行疗效判定。
结果：共有68例完成试验，治疗组35例，对照组33例。治疗2周末治疗组显效1例，有效27例，无效7例；对照组显效2例，有效20例，无效11例，两组疗效差异无统计学意义。但治疗1周末治疗组关节肿胀的评分为(4.0±1.4)分，低于对照组的(5.5±1.9)分。
结论：奇正青鹏膏剂治疗类风湿性关节炎与双氯芬酸二乙胺乳胶剂缓解关节疼痛疗效相当，奇正青鹏膏剂消肿作用更强。 |
| 【关键词】关节炎,类风湿 外治法 中药疗法 临床对照试验 |
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| Controlled clinical trials of external using of Cheezheng Qingpeng ointment(奇正青鹏膏) on reliving analgesia and swelling for the treatment of rheumatoid arthritis |
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ABSTRACT
Objective: To observe the clinical efficacy on analgesia and detumescence of Cheezheng Qingpeng ointment(奇正青鹏膏) in the treatment of rheumatoid arthritis.
Methods: From December 2004 to May 2006,78 patients were divided into the treatment group and the control group randomly using PROC PLAN from SAS software. There were 40 patients in the treatment group,30 patients were male and 10 patients were female,with an average age of(48.2 ±9.7) years,who were treated with Cheezheng Qingpeng ointment(奇正青鹏膏) external treatment. Thirty-eight patients were in the control group,30 patients were male and 8 patients were female,with an average age of(47.7 ±13.7)years,and were treated with Diclofenac diethylamine emugel. All the patients were treated for 2 weeks. The metacarpophalangeal joint with most severe pain and swelling was observed. The indexes including joint pain,tenderness,swelling,joint motion and morning stiffness were detected and the VAS scores were compared between the two groups.
Results: All the patients completed the trial,35 patients in the treatment group and 33 patients in the control group. At the end of 2 weeks,1 patient in the treatment group obtained an excellent result,27 good and 7 bad;in the control group,2 patients got an excellent result,20 good and 11 bad. There were no statistically difference of therapeutic effects between the two groups. At the 1st week after treatment,the joint swelling score of the treatment group was(4.0±1.4),which was lower than the(5.5±1.9)in the control group.
Conclusion: There is no obvious difference of therapeutic effects between Cheezheng Qingpeng ointment(奇正青鹏膏) and diclofenac diethylamine emugel for the treatment of rheumatoid arthritis,but the relieving of swelling of Cheezheng Qingpeng ointment(奇正青鹏膏)is better than that of Diclofenac Diethylamine Emugel. |
| KEY WORDS Arthritis,rheumatoid External therapies Drug therapy Controlled clinical trial |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 周彩云,潘峥,马芳,唐今杨.奇正青鹏膏剂外用治疗类风湿关节炎止痛消肿作用的临床对照试验[J].中国骨伤,2009,22(12):917~919 |
| 英文格式: | ZHOU Cai-yun,PAN Zheng,MA Fang,TANG Jin-yang.Controlled clinical trials of external using of Cheezheng Qingpeng ointment(奇正青鹏膏) on reliving analgesia and swelling for the treatment of rheumatoid arthritis[J].zhongguo gu shang / China J Orthop Trauma ,2009,22(12):917~919 |
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