| 正常健康人群外周血液中OPG和sRANKL浓度测定 |
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| 作者 | Author | 单位 | Address | E-Mail |
| 朱亮亮 |
ZHU Liang-liang |
南京大学医学院临床学院 南京军区南京总医院骨科,江苏 南京 210002 |
Department of Orthopaedics,Nanjing School of Clincal Medicine,Nanjing University/Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002,Jiangsu,China |
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| 包倪荣 |
BAO Ni-rong |
南京大学医学院临床学院 南京军区南京总医院骨科,江苏 南京 210002 |
Department of Orthopaedics,Nanjing School of Clincal Medicine,Nanjing University/Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002,Jiangsu,China |
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| 周利武 |
ZHOU Li-wu |
南京大学医学院临床学院 南京军区南京总医院骨科,江苏 南京 210002 |
Department of Orthopaedics,Nanjing School of Clincal Medicine,Nanjing University/Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002,Jiangsu,China |
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| 郭亭 |
GUO Ting |
南京大学医学院临床学院 南京军区南京总医院骨科,江苏 南京 210002 |
Department of Orthopaedics,Nanjing School of Clincal Medicine,Nanjing University/Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002,Jiangsu,China |
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| 曾晓峰 |
ZENG Xiao-feng |
南京大学医学院临床学院 南京军区南京总医院骨科,江苏 南京 210002 |
Department of Orthopaedics,Nanjing School of Clincal Medicine,Nanjing University/Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002,Jiangsu,China |
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| 赵建宁 |
ZHAO Jian-ning |
南京大学医学院临床学院 南京军区南京总医院骨科,江苏 南京 210002 |
Department of Orthopaedics,Nanjing School of Clincal Medicine,Nanjing University/Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002,Jiangsu,China |
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| 期刊信息：《中国骨伤》2010年，第23卷，第2期，第87-89页 |
| DOI：10.3969/j.issn.1003-0034.2010.02.003 |
| 基金项目: |
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中文摘要:
目的：对正常健康人群外周血液中骨保护素(Osteoprotegerin,OPG)、核因子kappaB受体活化因子配体(receptor activator of NF-κB ligand,RANKL)浓度测定，明确其与年龄、性别之间是否存在一定关系。
方法：收集220例正常健康人的清晨外周血液，其中男108例，女112例；年龄35～70岁，平均52.5岁。用ELISA法测血清中OPG、sRANKL浓度。
结果：在35～70岁正常健康人群外周血液中的OPG、sRANKL浓度：女性，OPG 21.95～315.47 pg/ml,sRANKL 10.25～370.20 pmol/L;男性，OPG 14.78～192.55 pg/ml,sRANKL 9.25～300.32 pmol/L.46岁后女性血液中OPG浓度与年龄存在正相关；57岁后女性血液中sRANKL浓度明显升高。
结论：年龄和性别影响外周血液中OPG、sRANKL浓度。46岁后女性血液中OPG浓度随年龄增加而升高，女性血液中sRANKL浓度57岁后明显升高。 |
| 【关键词】骨保护素 核激活因子受体配体 浓度测定 外周血 健康人 |
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| Concentration measurement of the OPG and sRANKL of peripheral blood among normal healthy people |
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ABSTRACT
Objective: To measure the concentration of osteoprotegerin(OPG) and receptor activator of NF-κB ligand (sRANKL) in peripheral blood among normal healthy people and investigate the relationship pf the concentration with age and sex.
Methods: The peripheral blood samples of 220 normal healthy people (included 108 males and 112 females,aged from 35 to 70) were collected in the morning. The OPG and sRANKL concentration of blood serum were measured by ELISA.
Results: The concentrations in female peripheral blood were:OPG 21.95 to 315.47 pg/ml,sRANKL 10.25 to 370.20 pmol/L;while in male were:OPG 14.78 to 192.55 pg/ml,sRANKL 9.22 to 300.32 pmol/L. There was positive correlation between the OPG concentration and age in the females older than 46 years. And for female older than 57,the sRANKL concentration of peripheral blood increases obviously.
Conclusion: Age and sex are the elements that affect the OPG and sRANKL concentration in peripheral blood. For female older than 46,the OPG concentration of peripheral blood increases with age,while the sRANKL concentration of peripheral blood increases for females older than 57. |
| KEY WORDS Osteoprotegerin (OPG) Receptor activator of nuclear factor-κB ligand (RANKL) Concentration measurement Peripheral blood Healthy people |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 朱亮亮,包倪荣,周利武,郭亭,曾晓峰,赵建宁.正常健康人群外周血液中OPG和sRANKL浓度测定[J].中国骨伤,2010,23(2):87~89 |
| 英文格式: | ZHU Liang-liang,BAO Ni-rong,ZHOU Li-wu,GUO Ting,ZENG Xiao-feng,ZHAO Jian-ning.Concentration measurement of the OPG and sRANKL of peripheral blood among normal healthy people[J].zhongguo gu shang / China J Orthop Trauma ,2010,23(2):87~89 |
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