颈前动力失衡致兔颈肌及颈间盘变化的组织形态学研究
摘要点击次数: 1645   全文下载次数: 811   投稿时间:2010-02-09    
作者Author单位AddressE-Mail
于栋 YU Dong 北京王府中西医结合医院骨科,北京 102209 Department of Orthopaedics, Wangfu Hospital of the Integration of Traditional Chinese and Western Medicine, Beijing 102209, China cyd2003h@yahoo.com.cn 
吕美娃 LV Mei-wa 中国中医科学院望京医院  
李光厚 LI Guang-hou 北京王府中西医结合医院骨科,北京 102209 Department of Orthopaedics, Wangfu Hospital of the Integration of Traditional Chinese and Western Medicine, Beijing 102209, China  
王洪坤 WANG Hong-kun 北京王府中西医结合医院骨科,北京 102209 Department of Orthopaedics, Wangfu Hospital of the Integration of Traditional Chinese and Western Medicine, Beijing 102209, China  
期刊信息:《中国骨伤》2010年,第23卷,第11期,第849-852页
DOI:10.3969/j.issn.1003-0034.2010.11.016
基金项目:
中文摘要:

目的:观察颈前肌短缩痉挛所致颈椎动力失衡状态下,颈肌及颈间盘的组织形态学变化。

方法:健康成年大耳白兔30只,体重(2.75±0.25) kg,雌雄各半。单纯随机法分成模型组、假手术组,每组15只。采用手术方法制备动物模型,模型组将双侧胸锁乳突肌肌束中部,用医用硅胶硬管垫起致其短缩,建立颈椎动力失衡模型;假手术组仅切开暴露双侧胸锁乳突肌。于术后2个月同一时间,观察两组颈肌及颈间盘的大体及组织形态学变化,同时对两组肌纤维的数量及横截面积进行比较。

结果:术后2个月,模型组颈肌及颈间盘发生明显的组织形态学变化。假手术组未见明显形态学改变。模型组颈前肌与颈后肌肌纤维数量较假手术组均明显减少(P<0.05);同样,模型组颈前肌与颈后肌肌纤维横截面积亦变小(P<0.05),颈前肌变化较颈后肌明显。

结论:颈前肌短缩痉挛所致颈椎动力失衡可导致颈肌及颈间盘组织发生病理改变,为研究颈前肌异常动力失衡引发的早期颈椎病发病提供实验证据。
【关键词】肌痉挛  椎间盘  组织学技术  动物,实验
 
Histologic changes of the cervical muscles and intervertebral discs caused by dynamic dysequilibrium of anteriorly cervical muscles in rabbits
ABSTRACT  

Objective: To observe the histologic changes of the cervical muscles and intervertebral discs caused by dynamic dysequilibrium of frontally cervical muscles in rabbits.

Methods: Thirty healthy rabbits with an average age of two years,half males and half females,the mean of weight in(2.75±0.25) kg,were divided randomly into model group and the sham operation group with fifteen rabbits in each group. The hibateral sternocleidomastoid muscles of ribbits in the model group were shortened by medical pipe to estabish the new animal model(the model was cervical dynamic dysequilibrium);and in the sham operative group,only exposed hibateral sternocleidomastoid muscles by operation. At the same time after two months,the histologic changes of the cervical muscles and intervertebral discs in all ribbits were observed,meanwhile,the myofibrillar amount and its cross section area were compared between two groups.

Results: After operation,the cervical muscles and intervertebral discs had significant change in model group,but no obvious change in sham operative group. The myofibrillar amount of frontal cervical muscles and back cervical muscles in model group was obviously lower than that of sham operative group(P<0.05); likewise,the myofibrillar cross section area in model group was obviously lower than that of sham operative group(P<0.05); the frontal cervical muscles was obviously change than the back cervical muscles.

Conclusion: The cervical dynamic dysequilibrium caused by crispation of frontal cervical muscles can lead to pathologic degeneration of cervical muscles and intervertebral discs. The study may provide experimental proof for early cervical spondylopathy.
KEY WORDS  Muscle spasm  Intervertebral disk  Histological techniques  Animals,laboratory
 
引用本文,请按以下格式著录参考文献:
中文格式:于栋,吕美娃,李光厚,王洪坤.颈前动力失衡致兔颈肌及颈间盘变化的组织形态学研究[J].中国骨伤,2010,23(11):849~852
英文格式:YU Dong,LV Mei-wa,LI Guang-hou,WANG Hong-kun.Histologic changes of the cervical muscles and intervertebral discs caused by dynamic dysequilibrium of anteriorly cervical muscles in rabbits[J].zhongguo gu shang / China J Orthop Trauma ,2010,23(11):849~852
查看  查看/发表评论  下载PDF阅读器
关闭




版权所有:《中国骨伤》杂志社京ICP备12048066号  版权声明
地址:北京市东直门内南小街甲16号,100700
电话:010-64089487 传真:010-64089792 Email:zggszz@sina.com