| 补阳还五汤促进大鼠夹伤腓总神经功能恢复的实验研究 |
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投稿时间：2010-04-15
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| 作者 | Author | 单位 | Address | E-Mail |
| 周岚 |
ZHOU Lan |
南京中医药大学，江苏 南京 210029 |
Nanjing University of Traditional Chinese Medicine,Nanjing 210029,Jiangsu,China |
xiaoyun663399@163.com |
| 梅晓云 |
MEI Xiao-yun |
南京中医药大学，江苏 南京 210029 |
Nanjing University of Traditional Chinese Medicine,Nanjing 210029,Jiangsu,China |
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| 吴颢昕 |
WU Hao-xin |
南京中医药大学，江苏 南京 210029 |
Nanjing University of Traditional Chinese Medicine,Nanjing 210029,Jiangsu,China |
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| 谢辉 |
XIE Hui |
南京中医药大学，江苏 南京 210029 |
Nanjing University of Traditional Chinese Medicine,Nanjing 210029,Jiangsu,China |
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| 唐雪梅 |
TANG Xue-mei |
南京中医药大学，江苏 南京 210029 |
Nanjing University of Traditional Chinese Medicine,Nanjing 210029,Jiangsu,China |
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| 孙华林 |
SUN Hua-lin |
南通大学江苏省神经再生重点实验室 |
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| 期刊信息：《中国骨伤》2011年，第24卷，第3期，第249-252页 |
| DOI：10.3969/j.issn.1003-0034.2011.03.021 |
| 基金项目:国家自然科学基金资助项目(编号：30873228) |
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中文摘要:
目的：研究补阳还五汤(BYHWD)促进大鼠夹伤腓总神经功能恢复的作用。
方法：采用钳夹大鼠腓总神经建立周围神经损伤的动物模型。将造模后的30只雄性SPF级SD大鼠随机分为3组：BYHWD组，弥可保组和模型组。术后每日灌胃给药，术后18 d行足迹实验，测定展趾功能；行电生理检测测定神经传导速度，计算胫前肌湿重比和横截面积。
结果：①展趾功能：BYHWD组(-0.15±0.07)、弥可保组(-0.17±0.08)与模型组(-0.25±0.07)相比增高(P<0.01).②神经传导速度：BYHWD组(18.36±2.74) m/s、弥可保组(16.32±3.54) m/s与模型组(9.08±2.56) m/s相比加快(P<0.01及P<0.05);弥可保组与BYHWD组相比差异亦有统计学意义(P<0.05).③胫前肌湿重比：BYHWD组(64.21±2.92)%、弥可保组(62.43±3.21)%,与模型组(54.27±2.05)相比提高(P<0.01).④胫前肌横截面积：BYHWD组(654.21±42.92) cm2、弥可保组(638.43±93.21) cm2,与模型组(574.27±52.05)相比增加(P<0.01及P<0.05);弥可保组与BYHWD组相比差异也有统计学意义(P<0.05).
结论：BYHWD能加速大鼠展趾功能恢复，提高神经传导速度，延缓胫前肌横截面积和湿重比的减小，从而促进腓总神经损伤后的功能恢复。 |
| 【关键词】补阳还五汤 腓神经 创伤和损伤 益气活血 |
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| Experimental study on Buyang Huanwu Decoction(补阳还五汤) for promoting functional recovery of crushed common peroneal nerve in rats |
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ABSTRACT
Objective: To study the effects of Buyang Huanwu Decoction(补阳还五汤，BYHWD)on promoting functional recovery of crushed common peroneal nerve in rats.
Methods: Thirty Sprague-Dawley rats were subjected to produce common peroneal nerve injuries model,and the length of injury was 5 mm. All the rats were divided into 3 groups:BYHWD group,mecobalamin group and model group. The drugs were given by gavage daily for 18 days. Footprint test was performed at the 18th day after surgery to evaluate toe spread function(TSF). Electrophysiology was performed at the 18th day after operation to determine the nerve conduct velocity(NCV). The wet weight ratio and section area of tibial muscle were also measured.
Results: ①TSF:At the 18th day after operation,the TSF in BYHWD group(-0.15±0.07) increased significantly compared with that of model group(-0.25±0.07)(P<0.01);the TSF in mecobalamin group(-0.17±0.08) also increased notably compared with that of model group(P<0.01).② NCV:the NCV in BYHWD group[(18.36±2.74) m/s](P<0.01)and in mecobalamin group[(16.32±3.54) m/s](P<0.05) also increased significantly compared with that of model group[(9.08±2.56) m/s];there was striking variation between model group and mecobalamin group(P<0.05). ③Wet weight ratio:the wet weight ratio in BYHWD group[(64.21±2.92)%](P<0.01)and in mecobalamin group[(62.43±3.21)%](P<0.01) all increased significantly compared with that of model group[(54.27±2.05)%].④The section area of tibial muscle:the section area of tibial muscle in BYHWD group[(654.21±42.92) cm2](P<0.01)and in mecobalamin group[(638.43±93.21) cm2](P<0.01)all increased significantly compared with that of model group[(574.27±52.05) cm2];there was also striking variation between model group and mecobalamin group(P<0.05).
Conclusion: BYHWD can promotes functional recovery of crushed nerve as a result of accelerating recovery of TSF,raising NCV and delaying the decrease of tibial muscle section area and wet weight ratio. |
| KEY WORDS Buyang Huanwu Decoction Peroneal nerve Wounds and injuries Reinfrocing Qi activate blood |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 周岚,梅晓云,吴颢昕,谢辉,唐雪梅,孙华林.补阳还五汤促进大鼠夹伤腓总神经功能恢复的实验研究[J].中国骨伤,2011,24(3):249~252 |
| 英文格式: | ZHOU Lan,MEI Xiao-yun,WU Hao-xin,XIE Hui,TANG Xue-mei,SUN Hua-lin.Experimental study on Buyang Huanwu Decoction(补阳还五汤) for promoting functional recovery of crushed common peroneal nerve in rats[J].zhongguo gu shang / China J Orthop Trauma ,2011,24(3):249~252 |
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