| EphB4-EphrinB2双向信号传导在骨重建中的作用 |
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投稿时间：2012-11-16
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| 作者 | Author | 单位 | Address | E-Mail |
| 范文斌 |
FAN Wen-bin |
南京大学医学院临床学院 南京军区南京总医院骨科, 江苏 南京 210002 |
Department of Orthopaedics, Clinical Medical College of Nanjing University, Nanjing General Hospital of Nanjing Military Command, PLA, Nanjing 210002, Jiangsu, China |
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| 赵建宁 |
ZHAO Jian-ning |
南京大学医学院临床学院 南京军区南京总医院骨科, 江苏 南京 210002 |
Department of Orthopaedics, Clinical Medical College of Nanjing University, Nanjing General Hospital of Nanjing Military Command, PLA, Nanjing 210002, Jiangsu, China |
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| 包倪荣 |
BAO Ni-rong |
南京大学医学院临床学院 南京军区南京总医院骨科, 江苏 南京 210002 |
Department of Orthopaedics, Clinical Medical College of Nanjing University, Nanjing General Hospital of Nanjing Military Command, PLA, Nanjing 210002, Jiangsu, China |
bnrbnr@sina.com |
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| 期刊信息：《中国骨伤》2013年，第26卷，第8期，第705-708页 |
| DOI：10.3969/j.issn.1003-0034.2013.08.022 |
| 基金项目:国家自然科学基金青年基金项目(编号:81000814) |
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| 中文摘要:Eph-Ephrin双向信号传导机制是近年来细胞间的通讯机制的研究热点,在神经系统、血管内皮系统及肿瘤形成和转移方面发挥着重要的作用。研究发现该信号传导系统在骨重建中发挥重要作用。破骨细胞上存在EphrinB2配体,成骨细胞前体上存在EphB4受体,以细胞直接接触的方式,通过胞内酪氨酸激酶信号系统,在成骨细胞和破骨细胞内分别产生正向和反向信号,促进成骨细胞前体分化成熟,同时抑制破骨细胞功能,并促进其凋亡。 |
| 【关键词】信号传导 骨重建 综述文献 |
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| Effects of bidirectional EphB4-EphrinB2 signaling on bone remodeling |
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| ABSTRACT Bidirectional Eph-Ephrin signaling as a focal point of research in cell-cell communications is critical for generation of nerves and vesssels as well as invation and metastasis of tumor cells. The roles for Ephrin-Eph bidirectional signaling in bone remodeling were important. EphrinB2 is expressed on osteoblasts and EphB4 is expressed on osteoclasts. Forward signaling through the EphB4 receptor into mesenchymal precursors promotes osteoblast differentiation,while reverse signaling through the EphrinB2 ligand into osteoclast suppresses differentiation. Signaling between the ligand EphrinB2 and the receptors EphB4 explains bidirectional signaling between osteoblasts and osteoclasts,bone absorption and remodeling,which may lay a theoretical foundation for identifying drug targeting and preventing and treating bone loss. |
| KEY WORDS Signal transduction Bone remodeling Review literature |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 范文斌,赵建宁,包倪荣.EphB4-EphrinB2双向信号传导在骨重建中的作用[J].中国骨伤,2013,26(8):705~708 |
| 英文格式: | FAN Wen-bin,ZHAO Jian-ning,BAO Ni-rong.Effects of bidirectional EphB4-EphrinB2 signaling on bone remodeling[J].zhongguo gu shang / China J Orthop Trauma ,2013,26(8):705~708 |
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