| 炎性因子IL-1β、TNF-α与椎间盘退变关系的研究进展 |
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投稿时间：2016-01-03
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| 作者 | Author | 单位 | Address | E-Mail |
| 赵赫 |
ZHAO He |
北京中医药大学东直门医院骨科, 北京 100700 |
Department of Orthopaedics, Dongzhimen Hospital Affiliated to Medical University of Beijing, Beijing 100700, China |
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| 俞兴 |
YU Xing |
北京中医药大学东直门医院骨科, 北京 100700 |
Department of Orthopaedics, Dongzhimen Hospital Affiliated to Medical University of Beijing, Beijing 100700, China |
yuxing34@sina.com |
| 唐向盛 |
TANG Xian-sheng |
北京中日友好医院骨科, 北京 100029 |
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| 贺丰 |
HE Feng |
北京中医药大学东直门医院骨科, 北京 100700 |
Department of Orthopaedics, Dongzhimen Hospital Affiliated to Medical University of Beijing, Beijing 100700, China |
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| 杨永栋 |
YANG Yong-dong |
北京中医药大学东直门医院骨科, 北京 100700 |
Department of Orthopaedics, Dongzhimen Hospital Affiliated to Medical University of Beijing, Beijing 100700, China |
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| 熊洋 |
XIONG Yang |
北京中医药大学东直门医院骨科, 北京 100700 |
Department of Orthopaedics, Dongzhimen Hospital Affiliated to Medical University of Beijing, Beijing 100700, China |
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| 胡振国 |
HU Zhen-guo |
北京中医药大学东直门医院骨科, 北京 100700 |
Department of Orthopaedics, Dongzhimen Hospital Affiliated to Medical University of Beijing, Beijing 100700, China |
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| 徐林 |
XU Lin |
北京中医药大学东直门医院骨科, 北京 100700 |
Department of Orthopaedics, Dongzhimen Hospital Affiliated to Medical University of Beijing, Beijing 100700, China |
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| 期刊信息：《中国骨伤》2017年，第30卷，第9期，第866-871页 |
| DOI：10.3969/j.issn.1003-0034.2017.09.017 |
| 基金项目: |
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| 中文摘要:IL-1β与TNF-α炎性因子作为椎间盘退变过程中的重要参与者日益受到国内外学者的关注。在椎间盘退变并最终导致下腰痛及神经根性症状全过程中，炎性因子从中起到重要的作用。在机械创伤、过度负荷、基因易感及感染等因素的作用下，纤维环及髓核细胞合成TNF-α、IL-1β。这些炎性因子在椎间盘退变过程中的作用大致可分为3个阶段。目前关于炎性因子在椎间盘退变病理生理过程中确切的调控机制仍需进一步研究，重点将在于阐述炎性因子在椎间盘退变中的调控机制、椎间盘退变的分子靶向治疗、细胞信号通路干预及寻找抗炎治疗的最佳时机上，为其将来的临床应用提供依据。 |
| 【关键词】IL-1β TNF-α 炎性因子 信号通路 椎间盘退变 |
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| Relationship between inflammatory cytokines of IL-1β and TNF-α and intervertebral disc degeneration |
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| ABSTRACT The inflammatory cytokines of IL-1β and TNF-α participate in the process of intervertebral disc degeneration is focused by the spine surgeons. Inflammatory cytokines represented by IL-1β and TNF-α act as the key factors in the process of intervertebral disc degeneration resulting in low back pain and radicular symptoms. Annulus fibrosus and nucleus pulposus can secrete TNF-α and IL-1β under the stimulation of mechanical injury,overstressed,genetic susceptibility and infection. The mechanism of inflammatory cytokines in intervertebral disc degeneration needs further investigation. The emphasis of researches will be on the inflammatory cytokines in the regulation of mechanism in the intervertebral disc degeneration,molecular targeted therapy,cell signaling pathways and the best time of anti-inflammatory therapy providing more evidence in the clinical application. |
| KEY WORDS IL-1β TNF-α Inflammatory cytokines Cell signaling pathways Intervertebral disc degeneration |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 赵赫,俞兴,唐向盛,贺丰,杨永栋,熊洋,胡振国,徐林.炎性因子IL-1β、TNF-α与椎间盘退变关系的研究进展[J].中国骨伤,2017,30(9):866~871 |
| 英文格式: | ZHAO He,YU Xing,TANG Xian-sheng,HE Feng,YANG Yong-dong,XIONG Yang,HU Zhen-guo,XU Lin.Relationship between inflammatory cytokines of IL-1β and TNF-α and intervertebral disc degeneration[J].zhongguo gu shang / China J Orthop Trauma ,2017,30(9):866~871 |
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