| 介孔氧化硅纳米材料在骨组织工程中的应用 |
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投稿时间：2019-06-18
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| 作者 | Author | 单位 | Address | E-Mail |
| 刘相辉 |
LIU Xiang-hui |
上海交通大学附属第一人民医院骨科, 上海 200080 |
Department of Orthopaedics, Shanghai 1st People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China |
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| 薛松 |
XUE Song |
上海交通大学附属第一人民医院骨科, 上海 200080 |
Department of Orthopaedics, Shanghai 1st People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China |
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| 马金忠 |
and MA Jin-zhong |
上海交通大学附属第一人民医院骨科, 上海 200080 |
Department of Orthopaedics, Shanghai 1st People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China |
majinzhong007@sina.com |
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| 期刊信息：《中国骨伤》2020年，第33卷，第8期，第784-787页 |
| DOI：10.12200/j.issn.1003-0034.2020.08.019 |
| 基金项目:国家自然科学基金（编号：81871795）；上海市科委项目（编号：13411950503；134119a2802） |
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| 中文摘要:组织工程骨作为一种极具潜力的新型骨移植材料，有效弥补了现今骨修复材料的缺陷。其中介孔氧化硅纳米材料由于具有比表面积大、生物相容性好、可进一步加工修饰等优点，适合骨组织工程对材料的需求，具有较好的应用前景。针对前期已开展的基础科学研究成果，本文综述了介孔氧化硅纳米生物材料的基本特性和其在骨组织工程中的应用优势，并从药物载体和支架成分两个方面综述了其在骨组织工程中的研究现状，其中药物载体方面主要介绍负载药物的种类和负载方法，支架成分方面则将含有介孔氧化硅纳米材料的支架分为无机支架、有机支架和复合支架三类，并标注了各种支架在微观结构、药物释放动力学、力学性质以及所培养细胞的分子学和细胞学行为等一个或多个方面的突出优点。此外，本文还介绍了介孔氧化硅纳米材料在骨粘合剂中的应用，以及金属离子的引入。最后对介孔氧化硅纳米生物材料在骨组织工程领域的发展方向提出了设想。 |
| 【关键词】介孔氧化硅 纳米材料 骨组织工程 骨修复 |
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| Mesoporous silica nanoparticles for bone tissue engineering |
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| ABSTRACT As a new potential bone graft material,tissue engineered bone effectively compensates for the defects of today's bone repair materials. Meanwhile,mesoporous silica nanomaterials(MSNs) have been widely recognized due to their large specific surface area,good biocompatibility,and capability of further processing and modification. They have promising application prospects in bone tissue engineering. For the basic scientific research results that have been carried out in the early stage,the basic characteristics of mesoporous silica nano-biomaterials and their application advantages,research status and development prospects in bone tissue engineering are reviewed. As for the research status,there are two aspects——as a carrier or as a component of engineering scaffolds. For the first aspect,different kinds of loaded drugs and different loading methods are reviewed. For the second,microstructure and mechanical properties of various complex scaffolds containing MSNs and the molecular and cellular behavior of seeded cells on these scaffolds are reviewed. The research of MSNs in bone cements and metal ions-doped MSNs in bone tissue engineering are also included. The future development of MSNs in bone tissue engineering is also discussed. |
| KEY WORDS Mesoporous silica Nanoparticles Bone tissue engineering Bone repair |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 刘相辉,薛松,马金忠.介孔氧化硅纳米材料在骨组织工程中的应用[J].中国骨伤,2020,33(8):784~787 |
| 英文格式: | LIU Xiang-hui,XUE Song,and MA Jin-zhong.Mesoporous silica nanoparticles for bone tissue engineering[J].zhongguo gu shang / China J Orthop Trauma ,2020,33(8):784~787 |
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