| 社区老年人群骨量丢失与膝骨关节炎患病率的相关性研究 |
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投稿时间：2024-06-11
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| 作者 | Author | 单位 | Address | E-Mail |
| 夏臣杰 |
XIA Chen-jie |
宁波大学附属李惠利医院骨科, 浙江 宁波 315040 |
Department of Orthopaedics, Li Huili Hospital Affiliated to Ningbo University, Ningbo 315040, Zhejiang, China |
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| 李瑾 |
LI Jin |
宁波大学附属李惠利医院骨科, 浙江 宁波 315040 |
Department of Orthopaedics, Li Huili Hospital Affiliated to Ningbo University, Ningbo 315040, Zhejiang, China |
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| 李翔 |
LI Xiang |
宁波大学附属李惠利医院骨科, 浙江 宁波 315040 |
Department of Orthopaedics, Li Huili Hospital Affiliated to Ningbo University, Ningbo 315040, Zhejiang, China |
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| 周珂 |
ZHOU Ke |
宁波大学附属李惠利医院骨科, 浙江 宁波 315040 |
Department of Orthopaedics, Li Huili Hospital Affiliated to Ningbo University, Ningbo 315040, Zhejiang, China |
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| 方亮 |
FANG Liang |
浙江中医药大学附属第一医院骨伤科, 浙江 杭州 310006 |
Department of Orthopaedics and Trauma- tology, the First Affiliated Hospital of Zhejiang Chinese Medicine University, Hangzhou 310006, Zhejiang, China |
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| 金红婷 |
JIN Hong-ting |
浙江中医药大学附属第一医院骨伤科, 浙江 杭州 310006 |
Department of Orthopaedics and Trauma- tology, the First Affiliated Hospital of Zhejiang Chinese Medicine University, Hangzhou 310006, Zhejiang, China |
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| 童培建 |
TONG Pei-jian |
浙江中医药大学附属第一医院骨伤科, 浙江 杭州 310006 |
Department of Orthopaedics and Trauma- tology, the First Affiliated Hospital of Zhejiang Chinese Medicine University, Hangzhou 310006, Zhejiang, China |
tongpeijian@163.com |
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| 期刊信息：《中国骨伤》2025年，第38卷，第4期，第358-363页 |
| DOI：10.12200/j.issn.1003-0034.20231278 |
| 基金项目:国家自然科学基金项目(编号:82104885);浙江省自然科学基金项目(编号:LQ22H270001);宁波市自然科学基金项目(编号:2023J215);宁波市重点学科(编号:2022-B01);宁波市医疗卫生高端团队重大攻坚项目(编号:2022020102) |
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中文摘要:
目的: 探究社区老年人群膝关节骨关节炎(knee osteoarthritis,KOA)的流行病学特点,及其与骨量丢失的相关性。
方法: 采用横断面研究设计,选取2017年8月至2018年1月浙江地区12家社区卫生服务中心的50岁以上老年人群进行面对面问卷调查,收集受试者的性别、年龄、身体质量指数(body mass index,BMI)、T值及KOA诊断结果。采用单因素回归分析年龄、性别、BMI及骨量丢失对KOA的影响,采用Logistic多因素回归分析骨量丢失对KOA的独立作用。
结果: 4 173例研究对象中,KOA患者1 710例,患病率为40.9%。KOA患者的年龄(65.5±3.8)岁,女性占比为67.7%(1 158/1 710),BMI (24.59±1.28) kg·m-2,高于非KOA受试者的(58.5±3.2)岁、51.3%(1 263/2 463)、(23.48±1.25) kg·m-2,差异均有统计学意义(P<0.001)。年龄60~69岁人群中,骨量减少、骨质疏松患者对KOA患病率的影响分别是[OR=1.21,95% CI (1.00,1.46),P=0.053 2],[OR=1.42,95% CI (1.14,1.78),P=0.002 2];男性、女性骨质疏松患者对KOA患病率的影响分别是[OR=1.52,95% CI (1.16,1.99),P=0.002 7],[OR=1.87,95% CI (1.51,2.32),P<0.000 1];24 kg·m-2 ≤ BMI<28 kg·m-2人群,骨量减少、骨质疏松患者对KOA患病率的影响分别是[OR=1.47,95% CI (1.21,1.80),P=0.000 1],[OR=2.69,95% CI (2.11,3.42),P<0.000 1]。在控制年龄、性别及BMI混杂因素作用后,与骨量正常人群比较,骨量减少对KOA患病率的影响[OR=1.34,95% CI (1.08,1.67),P=0.009 2],骨质疏松对KOA患病的[OR=1.38,95% CI (1.06,1.79),P=0.017 9]。
结论: 高龄超重女性更容易患KOA;骨量丢失是KOA患病的独立危险因素,会显著增加60~69岁或超重人群患KOA风险。 |
| 【关键词】膝骨关节炎 骨量丢失 横断面研究 相关性分析 |
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| Correlation between bone mass loss and incidence of knee osteoarthritis in the elderly community based population |
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ABSTRACT
Objective To explore the epidemiological characteristics of knee osteoarthritis (KOA) among the elderly in the community,and its correlation with bone mass loss.
Methods A cross sectional study was conducted on elderly community population over 50 year old from 12 community health service centers in Zhejiang province. Their gender,age,body mass index (BMI),T value and KOA diagnosis were collected using face to face questionnaire survey. Univariate regression was used to analyze the influence of age,gender,BMI and bone loss on KOA. Logistic multivariate regression model was used to analyze the independent effect of bone mass loss on KOA.
Results Among 4 173 subjects in this study,1 710 of them were had a KOA. The prevalence rate was 40.9%. The mean age,the proportion of females and the mean BMI in KOA patients were (65.5±3.8) years old,67.7%(1 158/1 710) and(24.59±1.28) kg·m-2,respectively,which were significantly higher than (58.5±3.2) years old, 51.3%(1 263/2 463),and (23.48±1.25) kg·m-2 in non-KOA subjects (P<0.001). In the population aged from 60 to 69 years old,the influence of osteopenia and osteoporosis on the prevalence of KOA was[OR=1.21,95%CI (1.00,1.46),P=0.053 2],[OR=1.42,95%CI (1.14,1.78),P=0.002 2]. The influence of male and female osteoporosis on the prevalence of KOA was[OR=1.52,95%CI(1.16,1.99),P=0.002 7] and[OR=1.87,95%CI(1.51,2.32),P<0.000 1],respectively. In the population of 24 kg·m-2 ≤ BMI<28 kg·m-2,the influence of osteopenia and osteoporosis on the prevalence of KOA was[OR=1.47,95%CI (1.21,1.80),P=0.000 1],[OR=2.69,95%CI(2.11,3.42),P<0.000 1],respectively. After controlling the confounding factors of age,gender and BMI,compared with people with normal bone mass,the effect of osteopenia on the prevalence of KOA was[OR=1.34,95%CI (1.08,1.67),P=0.009 2],and the effect of osteoporosis on the prevalence of KOA was[OR=1.38,95%CI (1.06,1.79),P=0.017 9].
Conclusion Elderly overweight women are more likely to develop KOA. Bone mass loss is an independent risk factor for KOA,which will significantly increase the prevalence of KOA in people overweight or aged 60 to 69 years old. |
| KEY WORDS Knee osteoarthritis Bone mass loss Cross sectional study Correlation analysis |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 夏臣杰,李瑾,李翔,周珂,方亮,金红婷,童培建.社区老年人群骨量丢失与膝骨关节炎患病率的相关性研究[J].中国骨伤,2025,38(4):358~363 |
| 英文格式: | XIA Chen-jie,LI Jin,LI Xiang,ZHOU Ke,FANG Liang,JIN Hong-ting,TONG Pei-jian.Correlation between bone mass loss and incidence of knee osteoarthritis in the elderly community based population[J].zhongguo gu shang / China J Orthop Trauma ,2025,38(4):358~363 |
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