| 中药单体调控骨髓间充质干细胞促进腱骨愈合机制的研究进展 |
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投稿时间：2025-04-27
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| 作者 | Author | 单位 | Address | E-Mail |
| 孟祥喆 |
MENG Xiang-zhe |
浙江中医药大学附属江南医院, 浙江 杭州 311201 |
Jiangnan Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 311201, Zhejiang, China |
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| 田观明 |
TIAN Guan-ming |
杭州萧山永信医院, 浙江 杭州 311223 |
Xiaoshan Yongxin Hospital, Hangzhou 311223, Zhejiang, China |
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| 韩雷 |
HAN Lei |
浙江中医药大学附属江南医院 杭州市萧山中医院骨科, 浙江 杭州 311201 |
Department of Orthopaedics, Jiangnan Hospital Affiliated to Zhejiang Chinese Medical University Hangzhou Xiaoshan Hospital of Traditional Chinese Medicine, Hangzhou 311201, Zhejiang, China |
hallen505@163.com |
| 王拓 |
WANG Tuo |
浙江中医药大学附属江南医院 杭州市萧山中医院骨科, 浙江 杭州 311201 |
Department of Orthopaedics, Jiangnan Hospital Affiliated to Zhejiang Chinese Medical University Hangzhou Xiaoshan Hospital of Traditional Chinese Medicine, Hangzhou 311201, Zhejiang, China |
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| 期刊信息：《中国骨伤》2025年，第38卷，第6期，第645-650页 |
| DOI：10.12200/j.issn.1003-0034.20240899 |
| 基金项目:浙江省自然基金(编号:LTGY24H270008;QN25H270007);浙江医药卫生科技计划(编号:2023KY231) |
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| 中文摘要:腱骨界面愈合是一个复杂的动态过程,涉及多种细胞和分子信号通路的相互作用。骨髓间充质干细胞(bone mesenchymal stem cells,BMSCs)具有分化为多种细胞的潜能,包括成骨细胞、成软骨细胞和脂肪细胞等,并具有再生受损组织的潜能,是促进腱骨愈合的潜在种子细胞。如何精确调控BMSCs的增殖和分化来加速腱骨愈合的进程是目前研究的热点。中药单体可通过调控Wnt/β-catenin、BMP/Smad等信号通路诱导BMSCs成骨、成软骨分化而促进腱骨愈合。通过相关信号通路对腱骨愈合的调控作用、中药单体及其调控BMSCs促进腱骨愈合的机制等方面的综述,以期为促进腱骨愈合提供新的思路。 |
| 【关键词】腱骨愈合 中药单体 骨髓间充质干细胞 中医药 综述 |
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| Mechanism of traditional Chinese medicine monomers on regulating bone marrow mesenchymal stem cells to promote tendon-bone healing |
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| ABSTRACT The healing of the tendon-bone interface is a complex dynamic process involving the interaction of multiple cellular and molecular signaling pathways. Bone mesenchymal stem cells (BMSCs) have the potential to differentiate into various types of cells,including osteoblasts,chondrocytes and adipocytes,etc.,and have the potential to regenerate damaged tissues. They are potential seed cells for promoting tendon bone healing. How to precisely regulate the proliferation and differentiation of BMSCs to accelerate the process of tendon bone healing is a current research hotspot. Monomers of traditional Chinese medicine can promote tendon bone healing by regulating signaling pathways such as Wnt/β-catenin and BMP/Smad to induce osteogenic and chondrogenic differentiation of BMSCs. This article reviews from several aspects such as the regulatory role of related signaling pathways on tendon-bone healing,traditional Chinese medicine monomers and their mechanism of regulating BMSCs to promote tendon-bone healing in order to providing new ideas for promoting tendon-bone healing. |
| KEY WORDS Tendon-bone healing Traditional Chinese medicine monomer Bone mesenchymal stem cells Traditional Chinese medicine Review |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 孟祥喆,田观明,韩雷,王拓.中药单体调控骨髓间充质干细胞促进腱骨愈合机制的研究进展[J].中国骨伤,2025,38(6):645~650 |
| 英文格式: | MENG Xiang-zhe,TIAN Guan-ming,HAN Lei,WANG Tuo.Mechanism of traditional Chinese medicine monomers on regulating bone marrow mesenchymal stem cells to promote tendon-bone healing[J].zhongguo gu shang / China J Orthop Trauma ,2025,38(6):645~650 |
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