膝骨关节炎炎性因子及信号通路的研究进展
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作者Author单位AddressE-Mail
王迷娜 WANG Mi-na 首都医科大学附属北京中医医院针灸中心 针灸神经调控北京市重点实验室, 北京 100010
北京中医药大学, 北京 100029
Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing 100010, China  
刘璐 LIU Lu 首都医科大学附属北京中医医院针灸中心 针灸神经调控北京市重点实验室, 北京 100010 Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing 100010, China  
赵洛鹏 ZHAO Luo-peng 首都医科大学附属北京中医医院针灸中心 针灸神经调控北京市重点实验室, 北京 100010
北京市中医研究所, 北京 100010
Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing 100010, China  
袁芳 YUAN Fang 首都医科大学附属北京中医医院针灸中心 针灸神经调控北京市重点实验室, 北京 100010 Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing 100010, China  
付渊博 FU Yuan-bo 首都医科大学附属北京中医医院针灸中心 针灸神经调控北京市重点实验室, 北京 100010 Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing 100010, China  
徐晓白 XU Xiao-bai 首都医科大学附属北京中医医院针灸中心 针灸神经调控北京市重点实验室, 北京 100010 Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing 100010, China  
李彬 LI Bin 首都医科大学附属北京中医医院针灸中心 针灸神经调控北京市重点实验室, 北京 100010 Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing 100010, China libin@bjzhongyi.com 
期刊信息:《中国骨伤》2020年,第33卷,第4期,第388-392页
DOI:10.12200/j.issn.1003-0034.2020.04.020
基金项目:
中文摘要:膝骨关节炎是关节炎中最常见的类型,以关节软骨变形、退化、患者感到关节疼痛活动不适为表现,影响了患者的生活质量,加重了社会的医疗负担。膝骨关节炎的发病机制十分复杂,本文对膝骨关节炎涉及的炎性因子及信号通路进行综述,发现所涉及的炎性因子大多为白细胞介素类,如IL-1β、IL-6、IL-15、IL-17、IL-18等,以及肿瘤坏死因子类,如TNF-α。这些炎性因子通过激活相应通路以及促进炎性介质释放,从而加重膝骨关节炎。膝骨关节炎涉及的炎性信号通路纷繁复杂,Notch通路、Wnt通路、SDF-1/CXCR4通路、TLRs通路、MAPKs通路、Hippo-YAP通路、OPG-RANK-RANKL通路和TGF-β通路等均可参与膝骨关节炎的调节,其中与炎性机制相关的通路以MAPKs通路、TLRs通路为主。不同的信号通路均可引起膝关节软骨的破坏,促进软骨细胞凋亡,最终导致膝关节内环境稳态的进一步失衡。同时,信号通路的激活又能促进炎性因子的释放,故在炎性因子与信号通路级联反应作用下,膝骨关节炎不断加重。
【关键词】骨关节炎,膝  信号通路  炎性因子  综述
 
Research of inflammatory factors and signaling pathways in knee osteoarthritis
ABSTRACT  Knee osteoarthritis is the most common type of arthritis,which is manifested by the deformation and degeneration of articular cartilage and the discomfort of patients with joint pain,which affects the quality of life of patients and aggravates the medical burden of society. The pathogenesis of knee osteoarthritis is very complex. This paper reviews the inflammatory factors and signal pathways involved in knee osteoarthritis. It is found that most of the inflammatory factors involved are interleukin,such as IL-1 β,IL-6,IL-15,IL-17,IL-18,and tumor necrosis factors,such as TNF-α. These inflammatory factors aggravate knee osteoarthritis by activating corresponding pathways and promoting the release of inflammatory mediators. The inflammatory signaling pathways involved in knee osteoarthritis are complex. Notch pathway,Wnt pathway,SDF-1/CXCR4 pathway,TLRs pathway,MAPKs pathway,hippo Yap pathway,OPG-RANK-RANKL pathway and TGF-β pathway are all involved in the regulation of knee osteoarthritis,and the pathways related to inflammatory mechanism are mainly MAPKs pathway and TLRs pathway. Different signaling pathways can cause the destruction of articular cartilage,promote the apoptosis of chondrocytes,and finally lead to the further imbalance of homeostasis in the knee joint. At the same time,the activation of signal pathway can promote the release of inflammatory factors,so under the cascade reaction of inflammatory factors and signal pathway,knee osteoarthritis is aggravating.
KEY WORDS  Osteoarthritis,knee  Signaling pathway  Inflammatory factors  Review
 
引用本文,请按以下格式著录参考文献:
中文格式:王迷娜,刘璐,赵洛鹏,袁芳,付渊博,徐晓白,李彬.膝骨关节炎炎性因子及信号通路的研究进展[J].中国骨伤,2020,33(4):388~392
英文格式:WANG Mi-na,LIU Lu,ZHAO Luo-peng,YUAN Fang,FU Yuan-bo,XU Xiao-bai,LI Bin.Research of inflammatory factors and signaling pathways in knee osteoarthritis[J].zhongguo gu shang / China J Orthop Trauma ,2020,33(4):388~392
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