|ABSTRACT [Abstract] Objective To investigate the efficacy and indications of PRP injection in the treatment of atrophic fracture nonunion. Methods From March 2015 to March 2017, 15 patients with atrophic fracture nonunion were treated with PRP injection. There were 10 males and 5 females, aged 23-56 years, with an average age of 40.0±9.1 years and a course of 6-14 months, average (8.87 ± 2.45) months. 60-100 ml peripheral blood was extracted to prepare PRP. The PRP platelet count was 587-1246×109/L, with an average of 947.13±158.58×109/L. Under the perspective, 13 to 20 ml of PRP was injected into the fracture end, and each injection was performed once in the first week and the second week of the treatment. It was reviewed once a month and evaluated by clinical examination and imaging examinations such as postoperative complications, whether the limb was shortened, angulation, and rotational deformity. Results All cases were followed up for 6-12 months with an average of 6.8±2.1 months. Compared with before treatment, the patients in this group had no shortening, angulation, and rotational deformity. 13 patients had fracture healing. The bone healing time was 4-6 months, with an average of 4.8±0.7 months. Two patients were 12 months. At the time of follow-up, there was no bone formation, and one of the screws was loose during treatment, and the other cases had no complications. Conclusion Atrophic fractures do not heal, and the stability of fracture ends after internal fixation is an indication for local PRP injection. PRP treatment of atrophic fractures can be completed under local anesthesia, safe operation and reliable efficacy.