|ABSTRACT Objective: Clinical study was conducted to investigate the efficacy of tranexamic acid in the control of intraarticular hemorrhage after shoulder arthroscopy. Method: From February 2018 to July 2018, 60 cases of rotator cuff tears treated by shoulder arthroscopy were randomly divided into observation group and control group, 30 cases in each group. In the observation group, there are 6 males and 24 females，55～70 years old, with an average age of（62.3±5.5）years and a course of disease of 2~36（11.7±1.7）months. In the control group, there were 5 males and 25 females,56～72 years old, with an average age of （63.4±5.8） years and a course of 4~36（10.8±1.4）months. The observation group received 0.5g of tranexamic acid (1g of tranexamic acid was diluted with normal saline to 20ml) in each articular cavity and Subacromial space after surgery. In the control group, 10ml of normal saline was injected into the joint cavity and Subacromial space respectively.The hemoglobin values of the two groups before and one day after operation were recorded. The circumference of shoulder joint was measured preoperatively and the 1st and 7th days after surgery. The circumference difference of shoulder joint was recorded. Complications such as subcutaneous blood stasis and DVT were recorded. Results: There was no statistically significant difference in hemoglobin values between the observation group and the control group before and the first day after surgery(P>0.05). On the first day after surgery, the peripheral diameter of the shoulder in the observation group (32.9±0.3)cm was significantly lower than that in the control group (35.1±0.5)cm, and the circumference difference of the shoulder (8.7±0.4)mm was also significantly lower than that in the control group (12.3±0.5)mm, the difference was statistically significant (P < 0.05).However, on the seventh day after surgery, there was no significant difference in the circumference of shoulder joint and the difference in the circumference of shoulder joint between the two groups(P>0.05). The number of cases of subcutaneous ecchymosis in the observation group (2 cases) was less than that in the control group (6 cases), but the difference between the two groups was not statistically significant(P>0.05).Conclusion: Subacromial and articular injection of tranexamic acid can significantly reduce the early soft tissue swelling after arthroscopic shoulder surgery, with good safety.