| 脊髓Ⅱ号对大鼠损伤脊髓轴浆运输的影响 |
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投稿时间：1996-12-30
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| 期刊信息：《中国骨伤》1997年，第10卷，第3期，第15-17页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目: |
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| 中文摘要:选取24只Wistar大白鼠,将其中18只制成胸髓右半侧横断损伤的大鼠模型,分别以脊髓Ⅱ号方剂、激素、生理盐水灌喂治疗。未造模的6只大鼠作为正常组,常规喂养。一个月后,注入辣根过氧化物酶(HRP),检测路经损伤区的上下行神经传导束始发核团中的标记细胞。发现脊髓Ⅱ号组HRP标记细胞数明显多于另两组,而与正常大鼠相比没有统计学上的显著差异。说明脊髓Ⅱ号方剂在恢复损伤传导来神经纤维的正常连续性,恢复神经元轴浆运输,促进神经细胞修复再生方面,有显著的效应。 |
| 【关键词】脊髓损伤 轴浆运输 脊髓Ⅱ号 |
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| Effect of Spinal Cord Ⅱ on Axoplasmic Transport in Injured Spinal Cord of Rat |
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| ABSTRACT Experimental models of right hemitransection of thoracic spinal cord were made in 18 Wistar rats and divided randomly into three groups:treated with Chinese herbs "Spinal Cord Ⅱ"(SC Ⅱ),hydrocortisone, and normal saline, respetively.6 intact rats were fed as usual. One month later,horseradish peroxidase (HRP)was injected into experimental rats, and the HRP labelled neurons in the originating nuclei of ascending
and descending nerve fiber bundles passing through the injured area were examined and counted under microscope. It was found that the number of HRP labelled neurons in SC Ⅱ group was prominently greater than that in hydrocortisone group and saline group (P<0.05),and there was no prominent difference in the number of HRP Labelled neurons between SC Ⅱ group and normal group (P>0.05).It was suggested that Spinal Cord Ⅱ can promote the recovery of normal continuity of injured nerve fibers, the axoplasmic transportation,and the regeneration of neurons in injured spinal cord. |
| KEY WORDS Injury of spinal cord Axoplasmic transport Spinal Cord Ⅱ(SC Ⅱ) |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 刘卫东,韩凤岳,景向红.脊髓Ⅱ号对大鼠损伤脊髓轴浆运输的影响[J].中国骨伤,1997,10(3):15~17 |
| 英文格式: | Liu Weidong,Han Fengyue,Jing Xianghong.Effect of Spinal Cord Ⅱ on Axoplasmic Transport in Injured Spinal Cord of Rat[J].zhongguo gu shang / China J Orthop Trauma ,1997,10(3):15~17 |
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