| 银杏叶提取液抗肢体缺血再灌注损伤 |
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投稿时间：2001-10-26
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| 期刊信息：《中国骨伤》2002年，第15卷，第8期，第471-472页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目: |
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中文摘要:
目的:观察银杏叶提取液对肢体缺血再灌注损伤的影响。
方法:制作兔肢体缺血再灌注损伤动物模型,并分为对照组、再灌注组和治疗组。检测不同时相点血小板计数、血栓素B2(TXB2)和6酮前列腺素F1α(6KetoPGF1α)含量,测定骨骼肌丙二醛(MDA)、线粒体钙(MitochondrialCa)含量和组织湿/干重量比值(Wet/Dry)。
结果:再灌注组与对照组比较,以上各项指标变化明显。银杏叶提取液可抑制血小板活化、降低血浆TXB2和6KetoPGF1α水平,减少骨骼肌MDA、线粒体Ca含量和组织湿/干重量比值。治疗组各项测定指标较再灌注组有比较明显改善。
结论:银杏叶提取液对肢体缺血再灌注损伤骨骼肌有保护作用。 |
| 【关键词】再灌注损伤 中医现代化 骨骼肌 |
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| The effect of Ginkgo Biloba Succi in combating platelet mediated injury of limb during ischemia and reperfusion |
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ABSTRACT
Objective:To observe the effect of Ginkgo Biloba Succi on ischemia and reperfusion injury of the limbs
Methods:The experimental models of ischemia and reperfusion injury of limb was produced in the rabbits which were divided into control group,reperfusion group and treatment group.The platelet count,TXB2 and 6 Keto PGF1α in plasma were assayed at different phase.The MDA,Mitochondrial Ca content and Wet/Dry ratio of skeletal muscle were measured respectively
Results:The index of reperfusion group changed significantly as compared with those of control group.Ginkgo Biloba Succi inhibited the platelet activation,reduced the level of TXB2 and 6 Keto PGF1α in plasma and decreased the MDA,Mitochondrial Ca content and Wet/Dry ratio of skeletal muscle.The index of treatment group improved significantly as compared with those of reperfusion group.
Conclusion:Ginkgo Biloba Succi might have the protective effect on muscle cells during ischemia and reperfusion injury of limb. |
| KEY WORDS Reperfusion injury Modernization of TCM Skeletal muscles |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 蓝旭,刘雪梅,葛宝丰,许建中.银杏叶提取液抗肢体缺血再灌注损伤[J].中国骨伤,2002,15(8):471~472 |
| 英文格式: | LAN Xu,LIU Xue mei,GE Bao feng.The effect of Ginkgo Biloba Succi in combating platelet mediated injury of limb during ischemia and reperfusion[J].zhongguo gu shang / China J Orthop Trauma ,2002,15(8):471~472 |
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