| 葛根汤对大鼠退变颈椎间盘组织前列腺素E2及环氧合酶的影响 |
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投稿时间：2002-06-03
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| 作者 | Author | 单位 | Address | E-Mail |
| 周军 |
ZHOU Jun |
中国中医研究院中药研究所,北京 100700 |
Institute of Chinese Materia Medica, China Academy of TCM Beijing, 100700, China |
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| 方素萍 |
FANG Su-ping |
北京广安门医院分子生物室 |
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| 霍海如 |
HUO Hai-ru |
中国中医研究院中药研究所,北京 100700 |
Institute of Chinese Materia Medica, China Academy of TCM Beijing, 100700, China |
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| 齐云 |
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中国中医研究院中药研究所,北京 100700 |
Institute of Chinese Materia Medica, China Academy of TCM Beijing, 100700, China |
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| 郭淑英 |
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中国中医研究院中药研究所,北京 100700 |
Institute of Chinese Materia Medica, China Academy of TCM Beijing, 100700, China |
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| 姜廷良 |
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中国中医研究院中药研究所,北京 100700 |
Institute of Chinese Materia Medica, China Academy of TCM Beijing, 100700, China |
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| 施杞 |
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上海中医药大学骨伤所 |
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| 期刊信息：《中国骨伤》2002年，第15卷，第12期，第724-726页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目:国家95攀登预选项目“中药现代化关键问题的基础研究”课题(970211018) |
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中文摘要:
目的:观察葛根汤对模型大鼠退变颈椎间盘组织PGE2及COX活性的影响,以探讨葛根汤治疗颈椎病的抗炎作用机理。
方法:选用动力失衡性颈椎病动物模型,造模后6个月,取出颈椎间盘组织,采用放免法、催化活性测定法分别测定PGE2含量及COX活性。
结果: 模型组PGE2含量及COX活性明显升高,葛根汤可下调PGE2的含量及抑制COX的活性。
结论:葛根汤下调退变颈椎间盘组织中PGE2的含量,与抑制COX活性密切相关,这可能是其治疗颈椎病的作用机制之一。 |
| 【关键词】中草药 颈椎病 前列素E2 环氧合酶 |
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| Effects of GeGen Decoction on PGE2 and COX in degenarated cervical intervertebral discs in rats |
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ABSTRACT
Objective:To explore the anti-inflammation mechanism of GeGen Decoction (GGD) on cervical spondylosis by investigating GGD on Prostaglandin E2(PGE2) and Cyclooxygenase (COX) activity in degenerated cervical intervertebral discs
Methods:Rats were modeled on the cervical dynamic unbalance, and 6 months later PGE2 content and COX activity in cervical intervertebral discs were measured by radioim-munoassay and catalytic activity assay, respectively.
Results:The PGE2 and COX activity were significantly higher in experimental groups;GGD could down-regulate the content of PGE2 and inhabit COX activity.
Conclusion:GGD could down-regulate the content of PGE2 activity in degenerated cervical intervertebral discs by inhabit COX activity, which may be one of its mechanisms in treating cervical spondylosis. |
| KEY WORDS Chinese herbal drugs Cervical vertebrae disease Prostaglandin E2 Cyclooxygenase |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 周军,方素萍,霍海如,齐云,郭淑英,姜廷良,施杞.葛根汤对大鼠退变颈椎间盘组织前列腺素E2及环氧合酶的影响[J].中国骨伤,2002,15(12):724~726 |
| 英文格式: | ZHOU Jun,FANG Su-ping,HUO Hai-ru.Effects of GeGen Decoction on PGE2 and COX in degenarated cervical intervertebral discs in rats[J].zhongguo gu shang / China J Orthop Trauma ,2002,15(12):724~726 |
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