| 去卵巢大鼠骨质疏松检测指标的实验分析 |
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投稿时间：2003-09-26
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| 作者 | Author | 单位 | Address | E-Mail |
| 孔焕宇 |
KONG Huan-yu |
中国中医研究院骨伤科研究所,北京100700 |
Institute of Orthopaedics and Traumatology,China Academy of TCM |
Konghy@263.net |
| 陈燕平 |
CHEN Yan-ping |
中国中医研究院骨伤科研究所,北京100700 |
Institute of Orthopaedics and Traumatology,China Academy of TCM |
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| 杨淑芹 |
YANG Shu-qin |
中国中医研究院骨伤科研究所,北京100700 |
Institute of Orthopaedics and Traumatology,China Academy of TCM |
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| 陈训华 |
CHEN Xun-hua |
中国中医研究院骨伤科研究所,北京100700 |
Institute of Orthopaedics and Traumatology,China Academy of TCM |
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| 周重光 |
ZHOU Chong-guang |
中国中医研究院骨伤科研究所,北京100700 |
Institute of Orthopaedics and Traumatology,China Academy of TCM |
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| 张万强 |
ZHANG Wan-qiang |
中国中医研究院骨伤科研究所,北京100700 |
Institute of Orthopaedics and Traumatology,China Academy of TCM |
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| 梁亚香 |
LIANG Ya-xiang |
中国中医研究院骨伤科研究所,北京100700 |
Institute of Orthopaedics and Traumatology,China Academy of TCM |
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| 宁可勇 |
NING Ke-yong |
中国中医研究院骨伤科研究所,北京100700 |
Institute of Orthopaedics and Traumatology,China Academy of TCM |
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| 闫兰 |
YAN Lan |
甘肃中医学院 |
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| 期刊信息：《中国骨伤》2004年，第17卷，第4期，第204-206页 |
| DOI：doi:10.3969/j.issn.1003-0034.yyyy.nn.zzz |
| 基金项目: |
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中文摘要:
目的:分析大鼠去势后不同时间体重、骨载荷、骨密度的变化及其相关性,为骨质疏松治疗药物研究中动物模型和实验指标的选择提供参考。
方法:5月龄雌性Wistar大鼠50只,随机分为模型组和正常组。两组分别于造模后3、9、13个月检测体重、骨密度和骨载荷。结果进行统计学分析。
结果:模型组体重明显高于正常组;两组腰椎载荷和骨密度出现显著性差异的时间均早于股骨;股骨骨密度出现明显下降的时间早于载荷;模型组骨密度低于正常组并与体重的增长呈负相关,模型组载荷低于正常组但与体重的增长呈正相关。
结论:去卵巢大鼠体重的变化可对载荷和骨密度产生不同影响,且不同部位的骨组织和不同年龄大鼠,骨量丢失存在差异。 |
| 【关键词】卵巢切除术 骨质疏松 骨密度 生物力学 动物,实验 |
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| Experimental analysis of osteoporotic detection marker of ovariectomized rats |
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ABSTRACT
Objective: To analyze the changes and the correlation of body weight,bone loading and bone mineral density in different time after ovariectomy of rats for providing reference of selection of animal model and experiment marker,in order to study the medicine of treatment osteoporosis.
Methods: 50 female Wistar rats with 5 months age were divided randomly into normal and ovariectomiged groups.The body weight,bone loading and bone mineral density were detected respectively after ovariectomy for 3,9,13 months.The results were analyzed statistically.
Results: The body weight of ovariectomized group was higher than that of normal group;loading and bone mineral density of lumbar vertebrae of normal and ovariectomized groups showed highly significant than that of femur.obviously descent of bone mineral density of femur was more early than that of loading of femur.bony mineral density and bony loading of ovariectomiged group were lower than that of normal group.To accompany with body weight gain,bony mineral density showed negative correlation but bony loading showed positive correlation.
Conclusion: The changes of body weight of the ovariectomiged female rats cause different effects.The amount of bony lose are different,according to the position of bone and the age of rat. |
| KEY WORDS Ovariectomy Osteoporosis Bone density Biomechanics Animals,laboratory |
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| 引用本文，请按以下格式著录参考文献： |
| 中文格式: | 孔焕宇,陈燕平,杨淑芹,陈训华,周重光,张万强,梁亚香,宁可勇,闫兰.去卵巢大鼠骨质疏松检测指标的实验分析[J].中国骨伤,2004,17(4):204~206 |
| 英文格式: | KONG Huan-yu,CHEN Yan-ping,YANG Shu-qin,CHEN Xun-hua,ZHOU Chong-guang,ZHANG Wan-qiang,LIANG Ya-xiang,NING Ke-yong,YAN Lan.Experimental analysis of osteoporotic detection marker of ovariectomized rats[J].zhongguo gu shang / China J Orthop Trauma ,2004,17(4):204~206 |
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